Calcium - Sensing Receptor Stimulates Cl - - and SCFA - dependent but Inhibits cAMP - 1 dependent HCO 3 - Secretion in Colon
نویسندگان
چکیده
Division of Gastroenterology, Nutrition and Hepatology, Department of Pediatrics, 4 University of Florida, Gainesville, FL, USA 5 Department of Pediatrics, Guangzhou Women and Children’s medical Center, 6 Guangzhou, Guangdong, PRC 7 Endocrine Research, VA Medical Center, University of California at San Francisco, San 8 Francisco, CA, USA 9 Department of Internal Medicine, Yale University, New Haven, CT, USA 10 11
منابع مشابه
Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon.
Colonic bicarbonate (HCO3(-)) secretion is a well-established physiological process that is closely linked to overall fluid and electrolyte movement in the mammalian colon. These present studies show that extracellular calcium-sensing receptor (CaSR), a fundamental mechanism for sensing and regulating ionic and nutrient compositions of extracellular milieu in the small and large intestine, regu...
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HCO(3)(-) secretion has long been recognized in the mammalian colon, but it has not been well characterized. Although most studies of colonic HCO(3)(-) secretion have revealed evidence of lumen Cl(-) dependence, suggesting a role for apical membrane Cl(-)/HCO(3)(-) exchange, direct examination of HCO(3)(-) secretion in isolated crypt from rat distal colon did not identify Cl(-)-dependent HCO(3)...
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Luminal isobutyrate, a relatively poor metabolized short-chain fatty acid (SCFA), induces HCO(3) secretion via a Cl-independent, DIDS-insensitive, carrier-mediated process as well as inhibiting both Cl-dependent and cAMP-induced HCO(3) secretion. The mechanism(s) responsible for these processes have not been well characterized. HCO(3) secretion was measured in isolated colonic mucosa mounted in...
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Anion secretion by colonic epithelium is dependent on apical CFTR-mediated anion conductance and basolateral ion transport. In many tissues, the NKCC1 Na(+)-K(+)-2Cl(-) cotransporter mediates basolateral Cl(-) uptake. However, additional evidence suggests that the AE2 Cl(-)/HCO(3)(-) exchanger, when coupled with the NHE1 Na(+)/H(+) exchanger or a Na(+)-HCO(3)(-) cotransporter (NBC), contributes...
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Background and purpose: Ât hunge state liver is the main source of synthesizing and secretion of low Density Lipoprotein (KLDL). For this purpose triacyleglycerol, phospholipids, cholestrol and its esters must be added to newly synthesized Âpo-B and secreted as a newly synthesized VLDL.VLDH metabolism is under hormonal and metabolic control, and stimulation of both ways is dependent on calciu...
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